Breakout Ventures has successfully closed its third fund at $114 million, dedicated to supporting early-stage startups that leverage artificial intelligence to advance scientific disciplines. The firm will target companies operating at the intersection of AI and fields such as biology and chemistry. With an investment strategy focused on unlocking scientific complexity through technology, Breakout plans to deploy capital in at least 20 new companies over the coming years. Average investment sizes per company are expected to range between $500,000 and $5 million. The firm has already committed funds to three companies and intends to make additional checks as the portfolio expands. Lindy Fishburne, the managing director of Breakout Ventures, told TechCrunch that the firm is specifically seeking organizations that utilize AI to solve massive unmet needs in the scientific sector. Established in 2016, the venture capital firm originated from a grant program by the Thiel Foundation. Prior to this latest raise, Breakout successfully launched Fund I in 2017 with $60 million and Fund II in 2021 with $112.5 million, both of which maintained a similar focus on science-based startups. Fishburne emphasized that the firm's mission has always been to harness the power of technology to commercialize breakthroughs in biology and chemistry, thereby creating new markets. The fundraising process for Fund III took approximately eighteen months. The capital was secured from a diverse group of limited partners, including The Kraft Group, Pinegrove Venture Partners, and Cubed Capital. When discussing the ideal profile for its portfolio companies, Fishburne noted that Breakout welcomes founders from various backgrounds. These include PhD researchers who developed the underlying science they are commercializing, as well as industry veterans who possess a deep understanding of specific market needs. Regardless of their background, the firm prioritizes a strong fit, seeking individuals who are uniquely positioned as the best candidates to build a specific company. This latest fund reinforces Breakout Ventures' commitment to the intersection of deep science and artificial intelligence. As AI capabilities continue to evolve, the firm believes this technology is essential for accelerating discovery and solving complex problems that traditional methods cannot address efficiently. By focusing on early-stage ventures, Breakout aims to provide the necessary financial support and strategic guidance to help these companies mature and scale. The success of this raise signals continued investor confidence in the potential of AI-driven scientific innovation. With a robust network of limited partners and a clear investment thesis, Breakout Ventures is well-positioned to drive the next wave of scientific breakthroughs. The firm expects to continue identifying and nurturing talent that can translate theoretical science into practical, market-ready solutions. This approach not only supports the growth of individual startups but also contributes to the broader advancement of the scientific community.