New AI Model Merging Medical Records with Multi-Omics Data Accurately Predicts Biological Age and Health Risks
Researchers at the University of Strathclyde have played a pivotal role in an international collaboration that introduces a groundbreaking method for measuring biological age. Published in Nature Aging, the study titled "OMICmAge quantifies biological age by integrating multi-omics with electronic medical records" was led by Harvard University. The research presents a novel aging model derived from comprehensive molecular data gathered across large-scale population studies. Unlike chronological age, which merely counts the number of years a person has lived, biological age reflects the cumulative physiological changes within the body. This metric can vary significantly between individuals of the same chronological age. To capture this complexity, the study developed the OMICmAge model using data from multiple biological layers, or "omics." These include DNA methylation, which regulates gene expression like an on/off switch, as well as proteins, metabolites, and other critical biological markers. The data was sourced from participants in the ORCADES and Generation Scotland cohorts. The findings demonstrate that OMICmAge consistently outperforms both traditional chronological age and existing single-omics aging clocks in predicting a wide array of health outcomes. Specifically, the model showed strong predictive power regarding physical and cognitive function. Furthermore, it identified significant associations with major age-related risk factors, including cardiovascular disease and diabetes. These results suggest that OMICmAge could serve as a powerful diagnostic tool for identifying individuals at higher risk of age-related decline before clinical symptoms manifest. Professor Nicholas Rattray from Strathclyde's Institute of Pharmacy and Biomedical Sciences, who contributed to the study's design and analysis, emphasized the transformative potential of this work. He noted that by integrating diverse molecular data with electronic health records, researchers can construct a far more accurate picture of an individual's biological state and its evolution over time. This integrative approach moves beyond simple age counting to offer deep insights into the biological mechanisms linking age to disease. While future studies are required to validate the model's performance in clinical settings, the current results indicate that OMICmAge is a promising resource for both research and healthcare applications. Beyond assessment, the model establishes a robust platform for investigating how lifestyle modifications, medication regimens, or environmental changes influence biological aging. Ultimately, understanding these dynamics could lead to targeted interventions designed to reduce disease risk and extend healthy lifespans. By bridging the gap between molecular data and medical records, this study marks a significant advancement in our understanding of the aging process and its impact on human health.
