At HPE Discover Las Vegas, running through June 18, Hewlett Packard Enterprise and NVIDIA unveiled a comprehensive expansion of the HPE AI Factory, engineered to transition enterprises from artificial intelligence proofs of concept to production-ready agentic workloads. The announcement establishes a standardized, full-stack infrastructure framework tailored for autonomous multi-agent systems and frontier-scale models exceeding one trillion parameters. Central to the update is the introduction of the NVIDIA Vera CPU, built specifically for agent orchestration, tool calling, and real-time data processing. The processor will launch in 2027 alongside HPE Private Cloud AI, with the New York Stock Exchange already piloting the architecture within HPE ProLiant Compute DL394 Gen12 servers. The Vera CPU forms the foundation of the NVIDIA Vera Rubin platform, which will deploy via the HPE ProLiant Vera Rubin NVL72 rack-scale system and the HPE Compute XD700, delivering up to 128 Rubin GPUs per chassis. To operationalize autonomous AI, NVIDIA Agent Toolkit is now integrated into HPE Private Cloud AI. The suite combines Nemotron open models, the OpenShell secure runtime, and NemoClaw blueprints, creating a dedicated operating system for multi-agent environments. Enterprises can enforce centralized governance through local agent registration and deploy HPE Zerto Software to detect anomalous agent behavior and instantly revert to secure states. Data preparation is streamlined via HPE Alletra Storage MP X10000, which auto-applies metadata and compliance policies to unstructured datasets, significantly boosting AI pipeline token throughput. Security remains a structural priority with NVIDIA Confidential Computing now native across the entire HPE AI Factory portfolio, including HPE AI Factory at Scale and HPE Sovereign AI Factory. The solution cryptographically protects sensitive data and proprietary models during execution, validated by the NVIDIA-Certified Systems program for HPE ProLiant Compute DL380a servers. In-silicon zero-trust enforcement and network encryption are delivered through NVIDIA BlueField DPUs and DOCA, safeguarding workloads without computational latency penalties. Infrastructure networking has been standardized around NVIDIA Spectrum-X Ethernet, now embedded across RTX PRO 6000 Blackwell Server Edition GPU deployments. Future Vera Rubin NVL72 systems will ship with pre-integrated Vera BlueField-4 DPUs, ConnectX-9 SuperNICs, and Spectrum-6 switching, delivering 1.6 times the communication performance of conventional Ethernet. For sovereign and large-scale deployments, NVIDIA Quantum-X800 InfiniBand options will remain available through the HPE Cray Supercomputing GX5000. The expansion coincides with the scaling of HPE Unleash AI, which onboarded over a dozen new software partners, including Thales, Vortiqx, and Aizen. Together, these integrated hardware, software, and ecosystem components provide a unified pathway for organizations deploying secure, high-throughput AI agents across hybrid and sovereign cloud environments.