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University of Strathclyde Researchers Develop Multi-Omics Model to Accurately Measure Biological Age and Predict Health Risks

Researchers at the University of Strathclyde have played a pivotal role in an international study introducing a groundbreaking method to measure biological age. The study, titled "OMICmAge quantifies biological age by integrating multi-omics with electronic medical records," was led by Harvard University and published in Nature Aging. This new model marks a significant advancement in understanding the aging process and predicting individual health outcomes. Unlike chronological age, which merely counts the number of years a person has lived, biological age reflects the cumulative physiological changes occurring within the body. These changes can vary dramatically between individuals of the same chronological age. To address this, the research team developed the OMICmAge model by integrating data from multiple "omics" layers. These layers include DNA methylation, which functions as a genetic on/off switch, as well as proteins, metabolites, and other critical biological markers. The data was drawn from large-scale population studies, specifically the ORCADES and Generation Scotland cohorts. The study demonstrates that OMICmAge consistently outperforms traditional chronological age and single-omic clocks in predicting a wide range of health outcomes. Key metrics include markers of physical and cognitive function, which are often early indicators of declining health. Furthermore, the model showed strong associations with major age-related risk factors, such as cardiovascular disease and diabetes. These findings suggest that OMICmAge could serve as a highly valuable tool for identifying individuals at a higher risk of age-related decline before symptoms become apparent. Professor Nicholas Rattray from the University of Strathclyde's Institute of Pharmacy and Biomedical Sciences, who contributed to the study design and analysis, emphasized the transformative potential of this approach. He noted that by combining data from the molecular landscape of the body with electronic health records, the team can build a far more accurate picture of an individual's biological state and how it evolves over time. This integrative method provides deeper insights into the links between biological age and disease than previously possible. While future studies will focus on evaluating the model's performance in clinical settings, the current results indicate that OMICmAge is a promising tool for both research and potential healthcare applications. Beyond diagnosis and risk assessment, the model offers a robust platform for investigating how lifestyle modifications, medications, or environmental changes can influence biological aging. Ultimately, this research opens new avenues for strategies aimed at reducing disease risk and extending healthy lifespans. By moving beyond simple age counting, scientists are gaining a precise lens through which to monitor human health and intervene effectively against the aging process.

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University of Strathclyde Researchers Develop Multi-Omics Model to Accurately Measure Biological Age and Predict Health Risks | Aktuelle Beiträge | HyperAI