Amalgam Rx, Inc., a pioneer in AI-powered healthcare decision-making, has announced the publication of two peer-reviewed research studies validating its Medical-Grade AI™ framework. The research, featured in the journals Artificial Intelligence and Applications and Human-Centric Computing, demonstrates how the company’s clinically governed AI system delivers both safety and high levels of patient engagement. The studies highlight the effectiveness of Amalgam’s multi-layered guardrails and personality-driven AI design in creating digital health experiences that are not only clinically reliable but also deeply engaging for users. Results showed that the platform doubled patient engagement compared to conventional digital health tools, a significant advancement in improving adherence and outcomes in chronic disease management and preventive care. The Medical-Grade AI™ framework is built on rigorous clinical oversight, ensuring that AI interactions remain accurate, ethical, and aligned with medical best practices. By integrating personalized communication styles with robust safety protocols, the system adapts to individual patient needs while minimizing risks associated with unregulated AI in healthcare. These findings underscore the growing importance of trustworthy, human-centered AI in digital health. As healthcare systems increasingly adopt AI-driven tools, Amalgam’s approach offers a model for balancing innovation with patient safety and meaningful interaction. The research was conducted in collaboration with leading academic institutions and healthcare providers, further strengthening the credibility of the results. Amalgam Rx continues to expand its platform’s capabilities, aiming to bring more intelligent, empathetic, and effective digital care solutions to patients and providers worldwide.