Antibody Antigen Binding Prediction

Antibody-antigen binding prediction involves assessing the degree of interaction between an antibody and its target antigen through computational or experimental methods, analyzing their sequences, structures, and physicochemical properties. This prediction is crucial for designing therapeutic antibodies, vaccines, and diagnostic reagents, and ensuring the accuracy of these predictions through experimental validation is essential for their value in biomedical research and development. The binding site prediction task focuses on identifying the antibody residues that interact with the antigen; if any heavy atom of an antibody residue is within 4.5 Å of a heavy atom of the antigen, the residue is considered part of the binding site.