Face alignment is a critical topic in the computer vision community. Numerous efforts have been made and various benchmark datasets have been released in recent decades. However, two significant issues remain in recent datasets, e.g., Intra-Dataset Variation and Inter-Dataset Variation. Inter-Dataset Variation refers to bias on expression, head pose, etc. inside one certain dataset, while Intra-Dataset Variation refers to different bias across different datasets. To address the mentioned problems, we proposed a novel Deep Variation Leveraging Network (DVLN), which consists of two strong coupling sub-networks, e.g., Dataset-Across Network (DA-Net) and Candidate-Decision Network (CD-Net). Extensive evaluations show that our approach demonstrates real-time performance and dramatically outperforms state-of-the-art methods on the challenging 300-W dataset.