**Abstract:** Broadleaf plantain (*Plantago major*) and ribwort plantain (*Plantago lanceolata*) have long been staples in traditional medicine, particularly in Estonia, where they are commonly used to treat minor skin abrasions. The practice of placing a plantain leaf on a scraped knee to facilitate faster healing has been passed down through generations, rooted in the country's rich ethnomedical heritage. Recent scientific research has begun to validate these traditional uses, confirming that plantain species possess significant wound-healing, anti-inflammatory, and antimicrobial properties. This evidence suggests a potential role for plantain in the treatment of more complex conditions, including chronic Lyme disease, a persistent and often debilitating illness caused by the bacterium *Borrelia burgdorferi*. Chronic Lyme disease, which can affect multiple organ systems and last for months or even years after the initial infection, remains a challenging medical issue, with conventional treatments sometimes proving insufficient. The study of plantain's therapeutic effects could offer new insights and alternative treatment options for patients suffering from this condition. This abstract explores the traditional and scientific aspects of plantain use, highlighting its potential as a natural remedy in the management of chronic Lyme disease. **Key Events:** - Traditional use of plantain in Estonia for treating minor skin abrasions. - Scientific confirmation of plantain's wound-healing, anti-inflammatory, and antimicrobial properties. - Exploration of plantain's potential in treating chronic Lyme disease. **Key People:** - Not specified in the article, but includes traditional healers and modern researchers studying plantain. **Key Locations:** - Estonia, where the traditional use of plantain is widespread. - Various research institutions where scientific studies on plantain are conducted. **Time Elements:** - Generational use of plantain in traditional medicine. - Recent scientific studies validating the traditional uses of plantain. - Ongoing research into the potential of plantain for treating chronic Lyme disease. **Summary:** The article discusses the traditional use of broadleaf plantain and ribwort plantain in Estonia, where these plants are commonly applied to minor skin injuries to promote healing. This practice, passed down through generations, is based on the belief that plantain has natural healing properties. Modern scientific research has now provided empirical evidence supporting these claims, demonstrating that plantain species can accelerate wound healing, reduce inflammation, and combat microbial infections. Chronic Lyme disease, a condition that can persist for extended periods and affect multiple bodily systems, is a significant health concern that often requires prolonged and intensive treatment. Conventional therapies, such as antibiotics, can sometimes fail to provide complete relief, leading to a search for alternative and complementary treatments. The antimicrobial and anti-inflammatory properties of plantain, as confirmed by recent studies, suggest that these plants could be a valuable addition to the therapeutic arsenal against chronic Lyme disease. The article highlights the importance of ethnomedicine in preserving and transmitting traditional knowledge about natural remedies. It also emphasizes the potential for bridging this traditional wisdom with modern scientific research to develop new and effective treatments for chronic conditions like Lyme disease. By integrating the ancient practices of using plantain with contemporary medical science, there is hope for improving the outcomes for patients suffering from this complex illness. **Conclusion:** While the traditional use of plantain in Estonia has long been known, recent scientific studies have provided a solid foundation for understanding its therapeutic benefits. The potential of broadleaf and ribwort plantain in treating chronic Lyme disease is an exciting area of research that could offer new hope to patients who have not found sufficient relief through conventional methods. Further studies are needed to fully explore the efficacy and safety of plantain in this context, but the initial findings are promising and underscore the value of traditional medicine in modern healthcare.