Quantum technologies are becoming essential to the United States’ economic competitiveness, national security, and scientific leadership in the 21st century. Sustained U.S. leadership in quantum information science is vital to turning breakthroughs in computing, sensing, networking, and materials into secure, scalable technologies and industries, a skilled domestic workforce, and long-term strategic advantage. To secure this future, Congress must reauthorize the National Quantum Initiative (NQI). Signed into law on December 21, 2018, the bipartisan NQI marked the first time the U.S. established a coordinated, multi-agency strategy to advance quantum information science. By bringing together universities, national laboratories, and industry, the initiative enabled sustained investment, shared infrastructure, and the development of a world-class R&D ecosystem. Since its launch, the field has seen remarkable progress—improved qubit coherence, higher gate fidelities, and advances in system scaling—moving quantum platforms from isolated experiments toward scalable architectures. These milestones have clarified a viable path to useful quantum systems and underscored the importance of long-term, coordinated national investment. In December 2025, Under Secretary for Science Dr. Darío Gil testified before the House Science Committee, describing the current moment as the dawn of a scientific revolution. He introduced the Trump Administration’s “Genesis Mission,” a bold new effort to unite national laboratories, academia, and industry in building an integrated discovery platform capable of doubling the nation’s R&D productivity within ten years. Gil emphasized that AI and quantum computing are no longer separate technologies but foundational elements of a new class of supercomputers. Just as telescopes and microscopes transformed scientific observation, these converged systems will serve as the next generation of scientific instruments—enabling unprecedented insight into the natural world. Realizing this vision requires breaking down silos between disciplines and prioritizing the integration of AI and quantum technologies. The most transformative quantum applications will emerge not from isolated advancements, but from workflows where AI accelerates quantum research and quantum systems enhance AI capabilities. This convergence demands a strategic shift in how the U.S. approaches quantum development. The existing NQI framework, while instrumental in early-stage research, predates this deeper integration. Reauthorizing the NQI is essential to evolve the national strategy to reflect today’s technological landscape. A modernized NQI should explicitly support the fusion of AI, accelerated computing, and quantum processors—ensuring these technologies mature into practical, broadly accessible systems and securing U.S. leadership in this new era of computing. A key component of this vision is the development of quantum-GPU supercomputers—systems that seamlessly integrate classical computing (CPUs and GPUs) with quantum processors (QPUs) into a unified, high-performance platform. Scientifically useful quantum systems capable of hundreds of logical qubits and millions of operations depend not just on advanced hardware, but on tight system-level integration. Open, interoperable architectures are critical to enabling this integration across national labs, universities, and industry. AI is already central to overcoming major challenges in quantum computing—from real-time error correction and hardware calibration to discovering more efficient quantum algorithms. Leading U.S. institutions, including national labs, are now embedding AI supercomputing into their core quantum workflows. However, scaling these systems to fault-tolerant, open-access infrastructures requires federal leadership. Only the federal government can build and operate the large-scale testbeds needed to validate integrated architectures, demonstrate performance, and lay the foundation for a competitive commercial market. Agencies like the Department of Energy have set ambitious goals, including deploying a scientifically useful quantum supercomputer by 2028. Achieving these targets will require the NQI to shift from a discovery-focused program to one that enables system-level deployment and integration. Reauthorizing the NQI is not just about funding research—it’s about transforming U.S. leadership in science and technology. By aligning quantum, AI, and high-performance computing into a cohesive national mission, the U.S. can turn its research edge into lasting economic and strategic advantage. Congress must make this reauthorization a top priority to ensure American leadership endures through and beyond the AI era.