Cryogenic Electron Microscopy (cryo-EM)

Cryogenic Electron Microscopy (cryo-EM) is a high-resolution imaging technique that involves observing samples under an electron microscope at cryogenic temperatures to achieve three-dimensional reconstruction of biological macromolecules. This technology aims to resolve the intricate structures of complex biological systems, providing details at the atomic level, and is widely used in the study of proteins, viruses, and other biomolecules, driving the advancement of structural biology. As an important branch of computer vision, the image processing and analysis capabilities of cryo-EM are crucial for improving the accuracy of structural determination.